Tuscaloosa-Lakewood is a historic neighborhood in Durham developed during the early 20th century. The neighborhood is conveniently situated southwest of downtown Durham. Part of the neighborhood is a designated National Register Historic District.

The neighborhood has over 500 houses in a variety of styles, including Queen Anne, Craftsman, and bungalow. Homes, built from the 1920s to 1960s, are priced from the $100s to $400s. There are also newer homes in Lakewood built in the last few years, mostly by B. Wallace.

The north end of Tuscaloosa-Lakewood is currently experiencing an exciting revitalization. The Lakewood Shopping Center, previously partially abandoned, is being developed into a community Reuse Arts District by the Scrap Exchange, a nonprofit creative reuse center. The district will house artist studios, performance art spaces, a thrift store, community gardens, and much more.

In addition to the shopping center, there is much more going on in Lakewood. Cocoa Cinnamon, a popular Durham coffee shop, is opening a third location in Lakewood that will house a micro-roastery and made to order churros. The Lakewood, a restaurant and bar from Chef Phoebe Lawless, opened in 2017. Just down the street, County Fare, a unique venue that will host food trucks daily and around a beer garden, opened in 2018.

The neighborhood is bordered on the south end by Durham-Chapel Hill Road (15-501), which houses more established restaurants. Guglhupf, a bakery, cafe, and restaurant, has been serving delicious German-inspired baked goods, sandwiches, and much more since 1998. Guglhupf also boasts one of the prettiest patios in Durham for outdoor dining. Next door is Foster's Market, a gourmet food market and cafe serving sandwiches, salads, baked goods, and more. Further down the street, you'll find several classic Durham restaurants: Nanataco, Nana's, Happy China, and Thai Cafe.